Fourneau 2559
Fourneau 2559 - General Information
A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)
Pharmacology of Fourneau 2559
Fourneau 2559 is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.
Additional information about Fourneau 2559
Fourneau 2559 Indication: For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
Mechanism Of Action: It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Gallamine Triethiodide
Synonyms: Gallamine; Gallamine Iodide; Gallamine Triethiiodide; Gallamine Triiodoethylate; Gallamone Triethiodide; Gallamin Triethiodide; Gallamin; Gallamonum; Benzcurine Iodide; Benzkurin; Triiodoethylate de Gallamine
Drug Category: Neuromuscular Nondepolarizing Agents; Nicotinic Antagonists; Skeletal Muscle Relaxants
Drug Type: Small Molecule; Approved
Other Brand Names containing Gallamine Triethiodide: Flacedil; Flaxedil; Fourneau 2559; Gallaflex; Miowas G; Parexyl; Pirolakson; Pyrolaxon; Relaxan; Remyolan; Retensin; Sincurarine; Syncurarine; Tricuran;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Fourneau 2559: Not Available
Chemical IUPAC Name: 2-[2,6-bis(2-diethylaminoethoxy)phenoxy]-N,N-diethylethanamine
Chemical Formula: C24H45N3O3
Gallamine Triethiodide on Wikipedia: Not Available
Organisms Affected: Humans and other mammals
